Fingerprinting a killer: surveillance of the influenza virus by mass spectrometry
Identifieur interne : 001406 ( Main/Exploration ); précédent : 001405; suivant : 001407Fingerprinting a killer: surveillance of the influenza virus by mass spectrometry
Auteurs : Kevin M. Downard [Australie] ; Bethny Morrissey [Australie]Source :
- Analyst [ 0003-2654 ] ; 2007.
English descriptors
- Teeft :
- Assay, Base peak, Bind antibody, Blood cells, Chicken eggs, Complement fixation, Component antigens, Computer algorithm, Constant peak, Control spectrum, Determinant, Diverged strain, Downard, Epitope, Gene sequence, Hemagglutination inhibition, Hemagglutinin, Hemagglutinin antigen, Hong kong, Human population, Imaginary peak, Influenza, Influenza strains, Influenza virus, Maldi mass spectra, Mass spectra, Mass spectrom, Mass spectrometry, Microtitre plate, Monoclonal antibody, Pandemic, Peak areas, Peptide, Protein interactions, Relative area, Royal society, Single step, Spectrometry, Vaccine, Various reference strains, Virus, Whole virus.
Abstract
Influenza is a deadly virus that continues to kill and inflict illness and suffering the world over. Despite a global surveillance strategy, an annual response to vaccine preparation and the development of new anti-viral drugs to treat the virus ahead of, or after, infection, no cure exists. Future pandemics are a very real threat and countries have mobilised efforts to stockpile treatments and prepare for outbreaks. A new surveillance approach in which the structure and antigenicity of the virus can be rapidly screened by mass spectrometry is expected to have a greater role in the characterisation of emerging influenza strains, even at the site of an outbreak.
Url:
DOI: 10.1039/b701835e
Affiliations:
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Despite a global surveillance strategy, an annual response to vaccine preparation and the development of new anti-viral drugs to treat the virus ahead of, or after, infection, no cure exists. Future pandemics are a very real threat and countries have mobilised efforts to stockpile treatments and prepare for outbreaks. A new surveillance approach in which the structure and antigenicity of the virus can be rapidly screened by mass spectrometry is expected to have a greater role in the characterisation of emerging influenza strains, even at the site of an outbreak.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Downard, Kevin M" sort="Downard, Kevin M" uniqKey="Downard K" first="Kevin M." last="Downard">Kevin M. 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